Professor Peter A. Lay ,Australian Professorial Fellow, School of Chemistry University of Sydney.
Brief CV:
The CI has presented invited and plenary lectures at international
conferences and institutions (60 since 1990 in Argentina, Denmark,
France, New Zealand, Switzerland, UK, Japan and USA and national level),
including: the International Conference on Biological Inorganic
Chemistry, 2003; International Coordination Chemistry Conference in
Endinburgh, 2000; the IUPAC World Congress of Chemistry,
Brisbane, 2001 (Burrows award lecture); Metals in Medicine
Gordon Conference in New Hampshire, 2002, Inorganic Reaction
Mechanisms Gordon Conference in California, 2001;
Asian Chemical Congress in Japan, 1997; 27th International
Symposium of the ESR Group of the Royal Society of Chemistry,
Cardiff, 1994; XVIIth International Conference on Organometallic
Chemistry, Brisbane, July, 1996; the review of the Advanced Photon
Source in Argonne (only non-American invited), 2001; and many
others spanning the disciplines of chemistry and biomedical research.
He has been appointed as a visiting professor at the University of Bern in 1991, a FOMEC Distinguished Professor at the University of Argentina in 1999, and a Personal Chair in Inorganic Chemistry in 1997.
The CI has received the Rennie Medal, Burrows Medal, and Fellowship of the Royal Australian Chemical Institute; and the Edgeworth David Medal of the Royal Society of NSW.
Finally, the applicant's research in the subject has been recognised by his appointment to the Editorial Advisory Committee of the American Chemical Society journal, Chemical Research in Toxicology in 2000 and Advances in Inorganic Chemistry in 2001. Since 1986, the applicant has been CI on a total of $10M in competitive grants.
Finally, the CI has co-supervised two Cornforth Medallists (awarded by RACI to the best chemistry PhD in Australia over the previous year).
Professor Lay has published at a rate of about 10 papers per year over the last five years with 70% in major international journals of the American Chemical Society and the Chemical Society (UK) (e.g., Impact Factors: JACS 5.725; Biochemistry 4.628; J. Phys. Chem. 4.173; Chem. Res. Toxicol. 3.336; Inorg. Chem 2.97; Chem. Commun. 3.407) and the remainder in other well-respected journals or invited reviews, articles and book chapters.
Prof. Lay's 176 career refereed publications and book chapters, have been highly cited. For the 132 papers listed in the ISI databank published before 2001, they were cited 2342 times (excluding self-citations) or an average of 17.7 per paper. If all papers up to the end of 2003 were included, there were 2398 citations (excluding self-citations) at an average of 15.6 per paper, but this is distorted by a large number of recent papers.
Brief summary of expertise and significant research achievements:
Professor Lay determined for the first time the Fe-ligand bond lengths
and Fe-NO angles of ferric nitrosyl hemeproteins using multiple-scattering
analysis of X-ray absorption fine structure using fluorescence detection of
the X-ray absorption spectrum from aqueous solutions. Such studies were
not accessible by other techniques such as XRD and their importance lies
in the understanding of the binding kinetics of NO and its varied biological roles.
Professor Lay's group was the first to use microprobe PIXE, SRIXE, and XAS for studying the spatial distribution and intracellular biotransformation of a carcinogen and hence, is at the cutting edge of the techniques that are based on the detection of fluorescent X-rays. He has been involved in new developments in the XAFS facilities at the Australian National Beamline Facility (ANBF) in Tsukuba, Japan, including heading a recent successful ARC LIEF grant for a new 36-element pixel detector for fluorescent X-rays at the ANBF. He has honed techniques for performing XAS experiments using fluorescent X-ray detection on very reactive and air-sensitive complexes, such as Cr(IV) and Cr(V) species and has made many ground breaking contributions to understanding the bioinorganic chemistry of Cr(VI) occupational cancers that have led to three invited reviews in Comments in Inorganic Chemistry, Coordination Chemistry Reviews and Progress in Inorganic Chemistry, and the APF is completing an invited chapter for Comprehensive Coordination Chemistry on Cr, which themselves are important contributions.
Professor Lay has made a total of nine successful visits to SSRL (international competition for beam time) to gather XAS data on heme proteins with all of the data having been analysed to produce precise information on Fe-ligand bond lengths and angles. They also have extensive experience in performing electrochemical and spectroscopic measurements on proteins, in particular, heme proteins. PALs group has used microbe PIXE at the University of Melbourne and XAS and SRIXE at Brookhaven and APS at Chicago and has made extensive use of the Australian National Beamline Facility at the Photon Factory in Japan for XAS measurements.
Evidence of Professor Lay's standing in the international community in the area of synchrotron radiation applications to bioinorganic chemistry and medicine are that he was: the only non-American to give an invited lecture at the review of the Advanced Photon Source (APS) in Chicago in 2001; he was an invited speaker and participant in the NIH-sponsored workshop to develop hard X-ray nanoprobe technologies for applications in medicine over the next five years (at the APS); he regularly receives beamtime on the highly sort after microprobe beamline at the APS; similarly he regularly obtains the full amount of time requested for XAFS at the ANBF in Tsukuba, Japan. He has also completed an invited review on multiple-scattering applications to inorganic and bioinorganic systems in a Specific Edition of Coordination Chemistry Reviews edited by Prof. Ed. Solomon. These attest to the international standing of the APFs credentials in the application of synchrotron radiation techniques to important problems in bioinorganic chemistry and medical/pharmaceutics.
International linkages:
Professor Lay has collaborations with the Stanford Synchrotron Research
Laboratory, the Advanced Photon Source at the Argonne National Laboratories
and at the Australian National Beamline Facility in Tsukuba, Japan.
He performs XAFS experiments for a range of groups throughout the world including: Professor Pat Farmer and Professor Frank Meyskens, University of California, Irvine; Professor Peter Wright, The Scripps Institute; Professor Surendra Mahapatro, Regis University, USA; Professor Dan Scherson, Case Western Reserve University; Professor Garry Roberts, University of Winconsin amongst others.
Students and postdocs likely to be involved in or use
the Network:
Dr. Aviva Levina, ARC Senior Research Associate
Dr. Anne Rich, ARC Postdoctoral Fellow
Dr. Ming-Chu Cheng, ARC Postdoctoral Fellow
Ms Irma Mulyani, PhD Student
Relevant grants:
| 2004-2006 | P. A. Lay, T. W. Hambley, S. G. Pearce, C. T. Dillon, Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects (including industry cash), ARC Linkage, $575,000. |
| 2003-2005 | P. A. Lay, R. S. Armstrong, A. Stampfl, Nanoprobe and Microprobe Spectroscopic Techniques in Drug Design, Probing Mechanisms of Diseases, and Bioinorganic Chemistry, ARC Discovery, $276,000. |
| 2002-2006 | P. A. Lay, The Chemistry and Biochemistry of Chromium: Cancer and Nutrition, ARC Discovery, $987,000 |
| 2001-2003 | P. A. Lay, N. M. Davies, J. E. Weder, T. W. Hambley, B. J. Kennedy, H. L. Regtop, J. R. Biffin, M. Craft, B. Warwick, New Metal Complexes of NSAIDs as Veterinary Eye Ointments, Anti-Cancer Drugs and General Anti-inflammatory Agents, ARC SPIRT (including industry cash contributions), $706,000 |
| 2001 | P.A. Lay, In vitro spectroscopic and structural studies of the metabolism of carcinogenic chromium(VI) complexes, ARC large, $92,000. |
| 2001-2002 | P. A. Lay, R. S. Armstrong, C. A. Reed, P. D. W Boyd, New developments in fullerene chemistry: Fullerenium Ions, Fullerene/Porphyrin Conjugates, Fullerenes Complexes, Fullerene Polymers and their applications, ARC IREX, $44,000. |
| 2003 | P. A. Lay, G. J. Foran, M. C. Ridgway, I. R. Gentle, S. P. Best, M. J. Riley, A. J. Berry, A. R. Gerson, T. W. Hambley, S. K. Bhargava, R. F. Garrett, D. C. Creagh, Fluorescence Detector for the Australian National Beamline Facility, ARC LIEF, $507,000. |
| 2003 | M. J. Riley, E. R. Krausz, P. A. Lay, R. J. Pace, New Generation Metalloenzyme Magnetic Circular Dichroism Spectrometer Systems, ARC LIEF, $390,000. |
| 2002 | L. N. Mander, M. J Crossley, L. D. Field, C. J. Easton, L. Radom, S. B. Wild, L. F. Lindoy, P. A. Lay, J. G. Collins, B. G. Rolfe, High Resolution Mass Spectrometer for (MS)n Chemical Characterisation, ARC LIEF, $900,000. |
| 2002 | E. M. Goldys, D. A. Veal, S. Prawer, R. S. Armstrong, P. A. Lay, R. J. Clarke, G. C. Cox, R. Cavicchioli, C. P. Roux, B. F. Usher, Novel Optical Microprobes - fluorescence excitation, lifetime and surface enhanced Raman spectroscopies, ARC LIEF, $352,000. |
| 2001 | L.D. Field, K.D. Barrow, P.A. Lay, M.J. Crossley, G.E. Ball, G.L. Mendz, R.G. Gilbert, NMR Spectroscopy Facilities, ARC REIF, $390,000. |
| 2003-2004 | P. A. Lay, P. Russell, Diagnosis of Breast Disease Using Vibrational Spectroscopy and Multivariate Analysis, University of Sydney, Cancer Research Fund, $95,500. |
| 2002 | P. A. Lay, R. S. Armstrong, In vivo and in vitro microprobe and nanoprobe spectroscopic techniques in drug design, probing mechanisms of disease and bioinorganic chemistry, University of Sydney, Sesqui Research Grant, $25,000. |
| 2004 | P. A. Lay, Nickel(III) and Nickel Dioxygen Peptide Complexes - Biomimetics of Biological Carcinogens and Enzymes, University of Sydney Sesqui R & D Grant, $20,000. |
| 2001-2002 | P. A. Lay, R. S. Armstrong, Stanford Synchrotron Radiation Laboratory, ANSTO, Access to Major Facilities Grants, $36,000. |
| 2001-2004 | P. A. Lay, Australian National Beamline Facility, Australian Synchrotron Research Program Grants, $58,000. |
| 2002-2003 | P.A. Lay, J. Aitken, C.T. Dillon. Micro-SRIXE and XANES investigations of the intracellular distributions and forms of Indoleamine 2,3-deoxygenase (IDO). Australian Synchrotron Research Program, APS. $24,000. |
| 2002-2004 | P. A. Lay, M. J. Davies, B. J. Kennedy, P. K. Witting, L-Band EPR Spectrometer, Wellcome Equipment Trust, $534,000. |
| 2003 | C.T. Dillon, P.A. Lay, J. Aitken. Micro-SRIXE and micro-XANES analysis of chromium compounds in lung cells: the "beneficial?" (dietary supplements) and the detrimental (carcinogens). Australian Synchrotron Research Program, Advanced Photon Source. $12,000. |
| 2001-2002 | C.T. Dillon, P.A. Lay, B.J. Kennedy. Micro-SRIXE investigations of the cellular uptake of the potential anti-inflammatory drugs, nickel, cobalt and copper indomethacin. Australian Synchrotron Research Program, Advanced Photon Source. $24,000. |
Relevant publications:
The following publications of the 176 career chapters and refereed articles involve research covered by this network.
a. Chapters and Chapter Sections in Books and Major Critical Review Articles
1. New Insights into the Mechanisms of Spontaneous and Base-Catalysed
Substitution Reactions of the Inert Metal Amine Complexes. Lay, P. A. Comments
Inorg. Chem. 1991, 11, 235-284.
2. Recent Advances in Osmium Chemistry. Lay, P. A.; Harman, W. D.
Advances in Inorganic Chemistry. Sykes, A. G.; Ed.; Academic Press: New York,
NY, 1991; Vol. 37; pp 219-379.
3. Recent Developments on the Mechanisms of Octahedral Substitution
Reactions. Lay, P. A. Coord. Chem. Rev. 1991, 110, 213-233.
4. New Insights into the Structures and Reactions of Chromium(V) Complexes:
Implications for Chromium(VI) and Chromium(V) Oxidations of Organic Substrates
and the Mechanisms of Chromium Induced-Cancers. Farrell, R. P.; Lay, P. A.
Comments Inorg. Chem. 1992, 13, 133-175.
5. Studies on the Genotoxicity of Chromium: From the Test Tube to the
Cell. Codd, R.; Dillon, C. T.; Levina, A.; Lay, P. A.
Coord. Chem. Rev. 2001, 216-217, 537-582.
6. Copper Complexes of Non-steroidal Anti-inflammatory Drugs:
An Opportunity yet to be Realized Weder, J. E.; Dillon, C. T.; Hambley, T. W.;
Kennedy, B. J.; Lay, P. A.; Biffin, J. R.; Regtop, H. L.; Davies, N. M.
Coord. Chem. Rev. 2002, 232, 95-126; invited contribution for a special
Biomedical issue.
7. Chromium in Biology: Nutritional Aspects and Toxicology.
Levina, A.; Codd, R.; Dillon, C. T.; Lay, P. A. Prog. Inorg. Chem.
2003, 51, 145-250.
8. Chromium, Levina, A.; Lay, P. A. in Comprehensive Coordination
Chemistry II, From Biology to Nanotechnology, McCleverty, J. A.; Meyer,
T. J., Eds. Volume 4, Wedd, A. J., Vol Ed., Elsevier, Oxford, UK, 2003,
Chapter 4.6, pp 313-413.
9. Copper and Zinc Complexes as Anti-Inflammatory Drugs. Dillon, C. T.;
Hambley, T. W.; Kennedy, B. J.; Lay, P. A.; Weder, J. E.; Zhou, Q. in
Metal Ions in "Metal Ions and Their Complexes in Medication",
Vol. 41 of 'Metal Ions in Biological Systems'; Sigel, A.; Sigel, H., Eds.;
M. Dekker, Inc., New York & Basel, 2004, Ch. 8, pp 253-277.
10. Three-Dimensional Structure Determination using Multiple-Scattering
Analysis of XAFS: Applications to Metalloproteins and Coordination Chemistry.
Levina, A.; Armstrong, R. S.; Lay, P.A. Coord. Chem. Rev.
(Special edition on "Synchroton Radiation in Inorganic and Bioinorganic
Chemistry", Solomon, E. I., Ed.) revised version submitted,
invited contribution
11. Mechanistic Studies of Relevance to the Biological Activities of
Chromium. Levina, A.; Lay, P.A. Coord. Chem. Rev. (Special edition on
"Inorganic Reaction Mechanisms", Ford, P. C., Ed.) submitted, invited
contribution
Articles, Notes and Communications Published in Refereed Journals:
12. Osmium(IV) Mediated Oxidative Dehydrogenation of Coordinated
Amines: Crystal and Molecular Structures of cis-(1,2-ethanediamine)
bis(1,2-ethanediaminato(1-))osmium(IV) Dibromide. Lay, P. A.;
Sargeson, A. M.; Skelton, B. W.; White, A. H. J. Am. Chem. Soc.
1982, 104, 6061-6064.
13. P Back-Bonding Effects of Osmium(III): Crystal Structure of
(m-Pyrazine)decaammine-diosmium(III) Chloride Dihydrate. Bino, A.;
Lay, P. A.; Taube, H.; Wishart, J. F. Inorg. Chem. 1985, 24, 3969-3971.
14. A Common Dissociative Interchange Mechanism for the Aquations of
Pentaaminechloro-cobalt(III) and -chromium(III) Complexes.
Lay, P. A. J. Chem. Soc., Chem. Commun. 1986, 1422-1423.
15. Comparisons of p Bonding and Hydrogen Bonding in Isomorphous
Compounds: [M(NH3)5Cl]Cl2 (M = Cr, Co, Rh, Ir, Ru, Os).
Hambley, T. W.; Lay, P. A. Inorg. Chem. 1986, 25, 4553-4558.
16. Evidence for Bond Breaking Substantially Preceding Bond Making in
the Mechanisms of Spontaneous Aquations of Penta-aminechlorochromium(III),
-cobalt(III) and -rhodium(III) Complexes: The Crystal and Molecular
Structure of Chloropentakis- (methylamine)rhodium(III) Chloride.
Hambley, T. W.; Lay, P. A. J. Chem. Soc., Chem. Commun. 1987, 865-866.
17. A Common Mechanism for the Spontaneous Aquations of Pentaaminecobalt(III)
and Pentaamine-chromium(III) Complexes. Ground-state Control Rather than
Activated-state Control of Kinetic Differences Between Cobalt(III) and
Chromium(III). Lay, P. A. Inorg. Chem. 1987, 26, 2144-2149.
18. Crystal and Molecular Structure of Tris(1,2-ethanediamine)osmium(III)
Trifluoromethanesulfonate Monohydrate. Lay, P. A.; McLaughlin, G. M.;
Sargeson, A. M. Aust. J. Chem. 1987, 40, 1267-1276.
19. Platinum(IV) Cage Chemistry: The Crystal Structure of
[1,8-bis(hydroxylamine)-3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane]
platinum(IV) Trifluoromethanesulfonate Monohydrate. Hagen, K. S.;
Lay, P. A.; Sargeson, A. M. Inorg. Chem. 1988, 27, 3424-342.
20. Electrochemistry of the Quasi-reversible Bis[2-ethyl-2-
hydroxybutanoato(2-)]oxo-chromate(V) and (IV) and Bis[2-hydroxy-2-
methylbutanoato(2-)]oxochromate-(V) and (IV) Redox Couples and
the Crystal and Molecular Structure of Sodium Bis[2-ethyl-2-
hydroxybutanoato(2-)]oxochromate(V) Sesquihydrate. Judd, R. J.;
Hambley, T. W.; Lay, P. A. J. Chem. Soc., Dalton Trans. 1989, 2205-2210.
21. The Structure of Pentaamminechlororuthenium(III) Sesquichloride
Hemi(tetrafluoroborate). Hambley, T. W.; Keyte, P.; Lay, P. A.;
Paddon-Row, M. N. Acta Crystallogr., Sect. C. 1991, C47, 941-943.
22. The Synthesis and Characterization of Pentaphenylcyclopentadienyl
Iron Arene Sandwich Complexes, [Fe(C5Ph5)(Arene)]+X-. Field, L. D.;
Hambley, T. W.; Lay, P. A., Lindall, C. M.; Masters, A. F.
J. Chem. Soc., Dalton Trans. 1991, 1499-1505.
23. The Synthesis and Crystal Structure of a V(V) Complex with a
2-Hydroxyacid Ligand, (NH4)2-[V(OC(CH2CH3)2COO)(O)2]2: A Structural
Model of Both Vanadium(V) Transferrin and Ribonuclease Complexes with
Inhibitors. Hambley, T. W.; Judd, R. J.; Lay, P. A.
Inorg. Chem. 1992, 31, 343-345.
24. Suppression by Vanadium(IV) of Chromium(V)-Mediated DNA Cleavage
and Chromium(V/VI)-Induced Mutagenesis. Synthesis and Crystal Structure
of the Vanadium(IV) Complex (NH4)-[V(O){HOC(Et)2COO}{OC(Et)2COO}].
Barr-David, G.; Hambley, T. W.; Irwin, J. A.; Judd, R. J.; Lay, P. A.;
Martin, B. D.; Bramley, R.; Dixon, N. E.; Hendry, P.; Ji., J.-Y.;
Baker, R. S. U.; Bonin, A. M. Inorg. Chem. 1992, 31, 4906-4908.
25. The Crystal and Molecular Structure of
(h5-Pentaphenylcyclopentadienyl)
(h5-cyclopentadienyl)iron(II), 1,2,3,4,5-Pentaphenylferrocene,
[Fe(C5Ph5)(C5H5)]. Aroney, M. J.; Buys, I. E.; Dennis, G. D.;
Field, L. D.; Hambley, T. W.; Lay, P. A.; Masters, A. F.
Polyhedron 1993, 12, 2051-2056.
26. The Synthesis and Structure of Ecapsulating Ligands:
Properties of Bicyclic Hexamines. Bottomley, G. A.; Clark, I. J.;
Creaser, I. I.; Engelhardt, L. M.; Geue, R. J.; Hagen, K. S.;
Harrowfield, J. M.; Lawrance, G. A.; Lay, P. A.; Sargeson, A. M.;
See, A. J.; Skelton, B. W.; White, A. H.; Wilner, F. R.
Aust. J. Chem. 1994, 47, 143-179.
27. Stabilization of Cobalt Cage Conformers in the
Solid State and Solution. Bernhardt, P. V.; Bygott, A. M. T.;
Geue, R. J.; Hendry; A. J.; Korybut-Daszkiewicz, B. R.;
Lay, P. A.; Pladziewicz, J. R.; Sargeson, A. M.; Willis, A. C.
Inorg. Chem. 1994, 33, 4553-4561.
28. A New Class of Layered Microporous Material: The Crystal
Structure of Disodium Pentakis-(trimethylphenylammonium)
Bis[tris(oxalato(2-))chromate(III)] Chloride Pentahydrate.
Farrell, R. P.; Hambley, T. W.; Lay, P. A.
Inorg. Chem. 1995, 34, 757-758.
29. Synthesis, Characterization and Crystal Structure of a
Vanadium(V)-(IV)-(V) Mixed-Valence Trimer with a Tridentate
Quinato Ligand, (NH4)2{[VV(O)2]2[VIV(O)](m-(-)-quinato(3-))2}.H2O.
Codd, R.; Hambley, T. W.; Lay, P. A. Inorg. Chem. 1995, 34, 877-882.
30. Investigation of the Uptake of Drugs, Carcinogens and
Mutagens by Individual Mammalian Cells Using a Scanning Proton
Microprobe. Cholewa, M.; Turnbull, I. F.; Legge, G. J. F.;
Weigold, H.; Marcuccio, S. M.; Holan, G.; Tomlinson, E.;
Wright, P. J.; Dillon, C. T.; Lay, P. A.; Bonin, A. M.
Nucl. Instrum. & Meth. B 1995, B104, 317-323.
31. The Crystal Structure of (2,2'-Bipyridine)(pyrazine)
(2,2':6',2"-terpyridine)ruthenium(II) Hexafluoro-phosphate.
Gulyas, P. T.; Hambley, T. W.; Lay, P. A. Aust. J. Chem. 1996, 49, 527-532.
32. Microprobe X-ray Absorption Spectroscopic Determination of
the Oxidation State of Intracellular Chromium Following Exposure
of V79 Chinese Hamster Lung Cells to Genotoxic Chromium Complexes.
Dillon, C. T.; Lay, P. A.; Cholewa, M.; Legge, G. J.F.; Bonin, A. M.;
Collins, T. J.; Kostka, K. L.; Shea-McCarthy, G.
Chem. Res. Toxicol. 1997, 10, 533-535.
33. Permeability, Cytotoxicty and Genotoxicity of Chromium(V) and
Chromium(VI) Complexes in V79 Chinese Hamster Lung Cells.
Dillon, C. T.; Lay, P. A.; Bonin, A. M.; Cholewa, M.; Legge, G. J. F.;
Collins, T. J.; Kostka, K. L. Chem. Res. Toxicol. 1998, 11, 119-129.
34. Determination of Iron-Ligand Bond Lengths in Horse Heart Met-
and Deoxy-Myoglobin Using Multiple-Scattering Analyses of XAFS Data.
Rich, A. M.; Armstrong, R. S.; Ellis, P. J.; Freeman, H. C.; Lay, P. A.
Inorg. Chem. 1998, 37, 5743-5753.
35. Determination of Fe-Ligand Bond Lengths and the Fe-N-O Bond
Angle in Horse Heart Ferric and Ferrous Nitrosylmyoglobin Using
Multiple-Scattering EXAFS Analyses. Rich, A. R.; Armstrong, R. S.;
Ellis, P. J.; Lay, P. A. J. Am. Chem. Soc. 1998, 120, 10827-10836.
36. Anti-Inflammatory Dinuclear Copper(II) Complexes with
Indomethacin. Synthesis, Magnetism and EPR Spectroscopy;
Crystal Structure of the N,N-Dimethylformamide Adduct.
Weder, J. E.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A.;
MacLachlan, D.; Bramley, R.; Delfs, C. D.; Murray, K. S.;
Moubaraki, B.; Warwick, B.; Biffin, J. R.; Regtop, H. L.
Inorg. Chem. 1999, 38, 1736-1744.
37. X-ray Absorption Spectroscopic Studies of the Chromium(IV)
2-Ethyl-2-hydroxybutanoato(1-) Complex. Levina, A.; Foran, G. J.;
Lay, P. A. J. Chem. Soc., Chem. Commun. 1999, 2339-2340.
38. Determination of Fe-Ligand Bond Lengths and the Fe-N-O Bond
Angles in Soybean Ferrous and Ferric Nitrosylleghemoglobin a Using
Multiple Scattering XAFS Analyses. Rich, A. M.; Ellis, P. J.;
Tennant, L.; Wright, P. E., Armstrong, R. S.; Lay, P. A.
Biochemistry 1999, 38, 16491-16499.
39. Determination of Iron-Ligand Bond Lengths in Ferric and Ferrous
Horse Heart Cytochrome c Using Multiple-Scattering Analyses of XAFS Data.
Cheng, M.-C.; Rich, A. M.; Armstrong, R. S.; Ellis P. J.; Lay, P. A.
Inorg. Chem., 1999, 38, 5703-5708.
40. Characterization and X-Ray Absorption Spectroscopic Studies of
Bis[quinato(2-)]oxochromate(V). Codd, R.; Levina, A.; Zhang, L.;
Hambley, T. W.; Lay, P. A. Inorg. Chem. 2000, 39, 990-997.
41. Permeability, Cytotoxicity, and Genotoxicity of Cr(III) Complexes
and Some Cr(V) Analogues in V79 Chinese Hamster Lung Cells. Dillon, C. T.;
Lay, P. A.; Bonin, A. M.; Cholewa, M.; Legge, G. J. F.
Chem. Res. Toxicol. 2000, 13, 742-748.
42. Syntheses and Characterization of Anti-inflammatory Dinuclear and
Mononuclear Zinc Indomethacin Complexes. Crystal Structures of
[Zn2(Indomethacin)4(L)2] (L = N,N-dimethylacetamide, Pyridine,
1-Methyl-2-pyrrolidinone) and [Zn(Indomethacin)2(L1)2] (L1 = Ethanol,
Methanol). Zhou, Q.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A.; Turner, P.;
Warwick, B.; Biffin, J. R.; Regtop, H. L. Inorg. Chem. 2000, 39, 3742-3748.
43. An Investigation of the Chromium Oxidation State of a Monoanionic
Chromium Tris(catecholate) Complex by X-ray Absorption and EPR
Spectroscopies. Pattison, D. I.; Levina, A.; Davies, M. J.; Lay, P. A.
Inorg. Chem. 2001, 40, 214-217.
44. Determination of the Structures of Antiinflammatory Copper(II)
Dimers of Indomethacin by Multiple-Scattering Analyses of X-ray Absorption
Fine Structure Weder, J.E.; Hambley, T. W.; Kennedy, B. J.;
Lay, P. A.; Foran, G. J.; Rich, A. M. Inorg. Chem. 2001, 40, 1295-1302.
45. In Situ Fe K-edge X-ray Absorption Spectroscopy of a Nitrosyl
Iron(II) Porphyrin Adduct Adsorbed on a High-Area Carbon Electrode
in Aqueous Electrolytes. Bae, I. T.; Tolmachev, Y.; Mo, Y.; Scherson, D.;
Scheidt, W. R.; Ellison, M. K.; Cheng, M.-C.; Armstrong, R. S.;
Lay, P. A. Inorg. Chem. 2001, 40, 3256-3258.
46. Dinuclear Chromium(V) Amino Acid Complexes from the Reduction of
Chromium(VI) in the Presence of Amino Acid Ligands: XAFS Characterization
of a Chromium(V) Amino Acid Complex. Headlam, H. A.; Weeks, C. L.;
Turner, P.; Hambley, T. W.; Lay, P. A. Inorg. Chem. 2001, 40, 5097-5105.
47. Preparation and Characterization of Dinuclear Copper-Indomethacin
Anti-Inflammatory Drugs. Morgan, Y. R.; Turner, P.; Kennedy, B. J.;
Hambley, T. W.; Lay, P. A.; Biffin, J. R.; Regtop, H. L; Warwick, B.
Inorg. Chim. Acta 2001, 324, 150-161. (Invited contribution).
48. High Resolution Nuclear and X-ray Microprobes and their
Applications in Single Cell Analysis, Cholewa, M.; Dillon, C. T.;
Lay, P. A.; Phillips, D.; Talarico, T.; Lai, B.; Balaic, D. X.;
Barnea, Z.; Cai, Z.; Deacon, G. B.; Ilinski, P.; Legnini, P.;
Rainone, S.; Shea-McCarthy, G.; Stampfl, A. P. J.; Webster, L. K.;
Yun, W.
Nucl. Instrum. & Meth. Phys. Res B 2001, 181, 715-722.
Erratum Nucl. Instrum. & Meth. Phys. Res B 2002, 198, 108-109.
49. Nickel(II) Complexes with Amide Ligands: Oxidative
Dehydrogenation of the Amines in a Tetradentate Diamide-Diamine
Ligand. Weeks, C. L.; Turner, P.; Fenton, R. R.; Lay, P. A.
J. Chem. Soc., Dalton Trans. 2002, 941-950.
50. Hard X-Ray Microprobe Studies of Chromium(VI)-Treated V79
Chinese Hamster Lung Cells: Intracellular Mapping of The
Biotransformation Products of a Chromium Carcinogen. Dillon, C. T.;
Lay, P. A.; Kennedy, B. J.; Stampfl, A. P. J.; Cai, Z.;
Ilinski, P.; Rodrigues, W.; Legnini, D. G.; Lai, B.;
Maser, J. J. Biol. Inorg. Chem. 2002, 7, 640-645.
51. Structure and Reactivity of a Chromium(V) Glutathione
Complex. Levina, A.; Zhang, L.; Lay, P. A.
Inorg. Chem. 2003, 42, 767-784.
52. Synthesis of the C59N+ Carbocation. A Monomeric
Azafullerene Isoelectronic to C60. Kim, K.-C.; Hauke, F.;
Hirsch, A.; Boyd, P. D. W.; Carter, E.; Armstrong, R. S.;
Lay, P. A., Reed, C. A. J. Am. Chem. Soc. 2003, 125, 4024-4025.
53. X-Ray Absorption Spectroscopic Studies of Chromium
Nitroso Complexes. Crystal and Molecular Structure of
(Ph4P)3[Cr(NO)(NCS)5]o2.4(CH3)2CO. Levina, A.; Turner, P.;
Lay, P. A. Inorg. Chem. 2003, 42, 5392-5398.
54. Synthesis of a Pyridinium Bis[citrato(2-)]oxochromate(V)
Complex and Its Ligand-Exchange Reactions Cawich, C. M.; Ibrahim, A.;
Link, K. L.; Bumgartner, A.; Patro, M. D.; Mahapatro, S. N.;
Lay, P. A.; Levina, A.; Eaton, S. S.; Eaton, G. R.
Inorg. Chem. 2003, 42, 6458-6468.
55. XAFS Studies of Anti-inflammatory Dinuclear and Mononuclear
Zn(II) Complexes of Indomethacin. Zhou, Q.; Hambley, T. W.;
Kennedy, B. J.; Lay, P. A. Inorg. Chem. 2003, 42, 8557-8566.
56. Solution Structures of Chromium(VI) Complexes with
Glutathione and Model Thiols. Levina, A.; Lay, P. A.
Inorg. Chem. 2004, 43, 324-335.
57. X-ray Absorption Spectroscopic and Electrochemical
Studies of Tris(catecholato(2-))chromate(V/IV/III) Complexes
Levina, A.; Foran, G. J.; Pattison, D. I.; Lay, P. A.
Agnew. Chem., Int. Ed. Engl. 2004, 43, 462-465.
58. X-Ray Absorption Spectroscopic Studies of
Chromium(V/IV/III) 2-Ethyl-2-hydroxybutanoato(2-/1-) Complexes.
Levina, A.; Codd, R.; Foran, G. J.; Hambley, T. W.;
Maschmeyer, T.; Masters, A. F.; Lay, P. A. Inorg. Chem., in press.
