Associate Professor Jennifer L Martin, Institute of Molecular Biology University of Queensland.
Brief CV:
A/Prof Martin is President of the Society of Crystallographers in Australia
and New Zealand (SCANZ) and was Queensland State representative
of the Australian Society for Biochemistry and Molecular Biology
(ASBMB) from 2000-2003. She is a Council member of Questacon (the
National Science and Technology Centre in Canberra) and a member of the
National Committee for Crystallography (a committee of the
Australian Academy of Sciences).
In 2002, A/Prof Martin joined the National Scientific Advisory Committee for the Australian Synchrotron Facility. She regularly review grants for NHMRC, ARC, Wellcome Trust and the NZHRC (and several other British & NZ funding bodies). Dr Martin is an ARC reader and was an NHMRC Discipline Panel member in 2001 and 2002. She is on the editorial board of J Struct and Functional Genomics and regularly review articles for other journals such as Structure, Eur J Biochem, Acta Cryst D, TIBS.
Brief summary of expertise and significant research achievements:
Dr Martin's career focus is the use of protein structure to better
understand protein evolution, function and folding and for
structure-based design. A/Prof Martin established a lab to target structures
of medically relevant proteins. This was the first protein
crystallography facility in Queensland and was also the first in Australia
headed by a woman. This was no mean feat in 1993, just
three years after her PhD was awarded. The lab is a very productive one and
strong collaborations have been forged not only within
UQ but elsewhere in Queensland and overseas. Furthermore, she have been
instrumental in the continued growth of structural biology
at UQ, which now boasts three protein crystallography groups. In 2001,
she was awarded an ARC RIEF grant of $1.1M which was used
with $1.5M from UQ to establish a world-class protein crystallography
facility including only the second installation in the world
of the high brilliance FR-E X-ray generator. In 2003, a LIEF grant of
$320K was awarded (Martin, Kobe, Quinn) with matched funds
from UQ and GU to establish high throughput protein expression screening
to accelerate structure determination.
Martin's lab has determined the structures of several important and medically
relevant proteins including adrenaline synthesizing enzyme
PNMT, human carcinogen converting enzyme SULT1A1, mammalian purple acid
phosphatase and bacterial virulence folding factors. In
addition, numerous HIV protease:inhibitor complexes have been determined,
which contributed to the development of novel inhibitors
with reduced propensity for viral resistance.
Website:
http://imb.uq.edu.au/index.html?id=11702
Relevant grants:
| Investigating the structure, function and inhibition of the adrenaline-synthesizing enzyme PNMT ARC Discovery Project ($270K over 3 years) Martin and Tyndall. |
| Structural studies on carbohydrate modifying enzymes ARC Linkage Project JL Martin and JA Halliday (Alchemia) $450K over 3 years. |
| Queensland high throughput structural biology screening facility ARC Linkage Infrastructure and Equipment Funding Martin, Kobe, Quinn $320,000. |
| Structure and function of novel macrophage proteins using high throughput crystallography" ARC Discovery Project, Martin & Kobe $600,000 over 3 years |
Relevant publications:
Martin JL, Johnson LN and Withers SG Comparison of the binding of glucose
and glucose 1-phosphate derivatives to T-State
glycogen phosphorylase Biochemistry 29, 10745-10757 (1990)
Martin JL, Veluraja K, Ross K, Johnson LN, Fleet GWJ, Ramsden NG,
Bruce I, Orchard MG, Oikonomakos NG, Papageorgiou AC, Leonidas
DD and Tsitoura HS Glucose analogue inhibitors of glycogen
phosphorylase: The design of potential drugs for diabetes
Biochemistry 30, 10101-10116 (1991)
Martin JL, Bardwell JCA and Kuriyan J Crystal structure of the
DsbA protein required for disulphide bond formation in vivo
Nature 365, 464-468 (1993)
Martin JL Thioredoxin - a fold for all reasons Structure 3, 245-250 (1995)
Hu S-H, Gehrmann J, Guddat LW, Alewood PF, Craik DJ and Martin JL
The 1.1 ¢ò Crystal structure of the neuronal acetylcholine
receptor antagonist, conotoxin PnIA from Conus pennaceus
Structure 4, 417-423 (1996)
Guddat LW, McAlpine AS, Hume D, de Jersey J, Hamilton S and
Martin JL ÈCrystal structure of mammalian purple acid phosphatase
Structure 7, 757-767 (1999)
Martin JL and McMillan FM (2002) SAM (dependent) I AM.
The S-adenosyl methionine dependent methyltransferase fold Curr Op
Struct Biol 12, 783-793
Gamage NU, Duggleby RG, Barnett AC, Tresillian M, Latham CF, Liyou NE,
McManus ME and Martin JL (2003) Structure of a human
carcinogen converting enzyme, SULT1A1: structural and kinetic implications
of substrate inhibition J Biol Chem 278, 7655-7662
