Dr Jose Varghese, Head Structural Biology CSIRO.
Brief CV:
B.Sc.(Hons) Theoretical Physics, University of Queensland 1970 Ph.D.
Physics, charge density and thermal studies, University of Western
Australia, 1974 SRC Postdoctoral Fellow, School of Molecular Sciences,
University of Sussex, Polarized neutron scattering, to 1980. CSIRO
Postdoctoral Fellow, Division of Protein Chemistry to 1983. CSIRO Senior
Scientist to 1990;
Seconded to the Biomolecular Research Institute to 2000;
CSIRO Head, Structural Biology 2000 to present.
Interests: Protein structure and function, structure based drug design, plant hydrolases, membrane receptor signalling, neurodegenrative diseases, X-ray optics.
Together with Prof Peter Colman and others pioneered development of anti-virial treatment of influenzna, using structure based drug design.
Relevant publications:
"Selected publications"
1. JN Varghese, WG Laver, PM Colman `Structure of the Influenza
Virus Glycoprotein Antigen Neuraminidase at 2.9 A Resolution' (1983)
Nature,303,5912,35-40.
2. PM Colman, JN Varghese, WG Laver `Structure of the catalytic and
antigenic sites in influenza virus neuraminidase' (1983)
Nature,303,5912,41-44.
3. PM Colman, WG Laver, JN Varghese, AT Baker, PA Tullock, GM Air,
RG Webster' Three-dimensional Structure of a Complex of Antibody with
Influenza Virus Neurimanidase '(1987) Nature.326,358-363.
4. JN Varghese, PM Colman 'Three-dimensional structure of the
neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution'
(1991) J.Mol.Biol.221,473-486.
5. JN Varghese, J McKimm-Breschkin, JB Caldwell, AA Kortt, PM
Colman ' The structure of the complex between influenza virus
neuraminidase and sialic acid, the viral receptor'
(1992)Proteins,14,327-332
6. M von Itzstein, W Wu, G Kok, MS Pegg, JC Dyson, B.Jin,TV Phan,
ML Smythe, HF White, SW Oliver, PM Colman, JN Varghese, DM Ryan, JM
Woods, RC Bethell, VJ Hotham, JM Cameron, CR Penn ' Rational design of
potent sialidase-based inhibitors of influenza virus replication'
(1993)Nature,363,418-423
7. JN Varghese, TPJ Garrett, PM Colman, L Chen, PB Hfj, GB Fincher
' The three-dimensional structures of two plant b-glucan endohydrolases
with distinct substrate specificities' (1994) Proc.Nat.Acad.Sci.USA
91,2785-2789.
8. JN Varghese, PW Smith, SL Sollis, TJ Blick, A Sahasrabudhe, JL
McKimm-Breschkin, PM Colman. 'A structural basis for resistance to
potent neuraminidase inhibitors in a variant of influenza virus' (1998)
Structure 6,735-746.
9. JN Varghese, M Hrmova, GB Fincher. 'Three-dimensional structure
of a barley 3 b-D-glucan exohydrolase, a family 3 glycosyl hydrolase'
(1999) Structure,7,179-190.
10. JN Varghese, RL Moritz, M-Z Lou, A vanDonkelaar, H Ji, N
Ivancic, KM Branson, NE Hall, RJ Simpson 'Structure of the extracellular
domains of the human interleukin-6 receptor a-chain'(2002)
